An in vivo study aimed at detecting dental monomers in patient saliva after restorative treatment with a composite material. Resin-based dental restorative materials contain monomers with potential for adverse reactions, which may be released into saliva after restorative treatment. Saliva was collected from ten patients at four time points – before treatment, and 10 min, 24 hours and 7 days after treatment. The presence and content of monomers in the saliva samples was determined through chromatography.

In the samples collected shortly after treatment (10 min), the monomers Bis-GMA, HEMA and UDMA were detected and quantified, in amounts ranging from 0.004 to 9.65 µg/ml saliva. TEGDMA was detected in four of the samples, while Bis-EMA was not found in any of the samples. The monomers detected in saliva originated from both the adhesive and the composite used in the treatment. Patient-to-patient variation was rather large, especially for Bis-GMA. Possible explanations are variation in residues of material after the dental treatment and the removal of the inhibition layer (through finishing and polishing) before sampling.

Monomers were not detected in saliva samples collected at longer time periods after treatment, with one exception. This may explain the low incidence of local adverse effects related to resin-based dental restorations.

This study was published in Eur J Oral Sci 2012; 120: 89–95.

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