Cell toxicity of 2-hydroxyethyl methacrylate (HEMA): the role of oxidative stress -

In this study, the viability of human lung epithelial cells, BEAS-2B, was investigated after exposure to this monomer. Exposure to HEMA reduced the viability of the BEAS-2B cells as a result of increased apoptosis, interruption of the cell cycle, and decreased cell proliferation.

Explaining the toxicity of methacrylate monomers -

A possible mechanism for the toxicity of methacrylate monomers is elucidated in a recent publication from NIOM. The resin matrix of dental restorative materials consists of combinations of methacrylate monomers like bisphenol A-glycidyl dimethacrylate (BisGMA), triethylene glycol dimethacrylate (TEGDMA) and glycerol dimethacrylate (GDMA) in composite fillings, while 2-hydroxyethyl methacrylate (HEMA) is a major constituent in most dental adhesives.

The monomer HEMA may interfere with DNA in vitro -

Dental treatment may expose both the patient and the dental professionals to 2-hydroxyethyl methacrylate (HEMA). The compound is a monomer commonly used in resin-based dental materials. Incomplete polymerization of dental resin components can result in release of monomer to the oral cavity.