Previously, we have reported data obtained from near-infrared reflection spectroscopy (NIRS) used to non-invasively monitor tissue changes after optical exposure. The results indicated that oral mucosa may be more sensitive than skin to blue light. In this pilot study, visible data from NIRS (VNIRS) was used to observe differences between exposure groups with respect to the following parameters: pigmentation (melanin index; MI), blood oxygenation (OX) and erythema (erythema index; EI).