Evidence for induction of cardiorespiratory and vascular complications by methylmethacrylate monomer in hip replacement surgery. Laboratory and animal investigations -

In vitro and in vivo studies have shown that MMA in different ways contribute to activation of coagulation. In addition, MMA per se is cytotoxic and may in clinically relevant concentrations cause disintegration of vascular and blood cells with potential release of proteolytic enzymes and exposure of subendothelial constituents.