Cell toxicity of methacrylate monomers-the role of glutathione adduct formation. -

Polymer-based dental restorative materials are designed to polymerize in situ. However, the conversion of methacrylate monomer to polymer is never complete, and leakage of the monomer occurs. It has been shown that these monomers are toxic in vitro; hence concerns regarding exposure of patients and dental personnel have been raised.

Sammendrag av doktorgradsavhandling: «Toxicity of resin based dental restorative materials in vitro» -

Artikkelens hensikt er å belyse toksisiteten av utvalgte metakrylatmonomerer i modeller som kan relateres til cellulære mål in vivo. En cellelinje med opphav fra spyttkjertel-epitel og primære epiltelceller fra rottelunge ble valgt som relevante modellsystemer. Monomerene 2- hydroxyetylmetakrylat (HEMA) og trietylenglykoldimetakrylat (TEGDMA) er to metakrylater som er mye brukt i resinbaserte tannbehandlingsmaterialer, og cellekulturene ble eksponert for disse i varierende konsentrasjon og varighet.

DNA damage, cell-cycle arrest and apoptosis induced in BEAS-2B cells by 2-hydroxyethyl methacrylate (HEMA). -

The methacrylate monomer 2-hydroxyethyl methacrylate (HEMA) is commonly used in resin-based dental restorative materials. These materials are cured in situ and HEMA and other monomers have been identified in ambient air during dental surgery. In vitro studies have demonstrated a toxic potential of methacrylates, and concerns have been raised regarding possible health effects due to inhalation. In this study we have investigated the mechanisms of HEMA-induced toxicity in the human lung epithelial cell line BEAS-2B..

Cytotoxicity of new resin-, calcium hydroxide- and silicone-based root canal sealers on fibroblasts derived from human gingiva and L929 cell lines -

To assess ex vivo the cytotoxic effects of five new root canal sealers (RC Sealer, Epiphany, EndoREZ, GuttaFlow and Acroseal) and three existing products (AH Plus, RoekoSeal and Apexit) using primary human gingival fibroblasts (HGF) and a mouse fibroblast cell line, L929.

Evidence for induction of cardiorespiratory and vascular complications by methylmethacrylate monomer in hip replacement surgery. Laboratory and animal investigations -

In vitro and in vivo studies have shown that MMA in different ways contribute to activation of coagulation. In addition, MMA per se is cytotoxic and may in clinically relevant concentrations cause disintegration of vascular and blood cells with potential release of proteolytic enzymes and exposure of subendothelial constituents.