Due to incomplete curing and material degradation, cells in the oral cavity may be exposed to monomers and filler particles from dental composite fillings. The objective of the present study was to investigate if combined exposures to particles and a methacrylate monomer from composite fillings resulted in additive effects on the macrophage immune response.

Commercial resin-based composites are mainly composed of dimethacrylate-based monomers, such as triethyleneglycol dimethacrylate (TEGDMA), inorganic fillers and a coupling agent. Cured resinbased composites have no antibacterial effect against oral bacteria and half of all fillings replaced are because of new caries . Chitosan is a natural carbohydrate polymer derived from the deacetylation of chitin. Chitosan has been shown to have an inhibitor effect on the adherence of oral bacteria onto human tooth surfaces.

Resin-based dental restorative materials contain allergenic methacrylate monomers, which may be released into saliva after restorative treatment. Monomers from resin-based composite materials have been demonstrated in saliva in vitro; however, studies analyzing saliva after restorative therapy are scarce. The aim of this study was to quantify methacrylate monomers in saliva after treatment with a resin-based composite filling material.

Artikkelens hensikt er å belyse toksisiteten av utvalgte metakrylatmonomerer i modeller som kan relateres til cellulære mål in vivo. En cellelinje med opphav fra spyttkjertel-epitel og primære epiltelceller fra rottelunge ble valgt som relevante modellsystemer. Monomerene 2- hydroxyetylmetakrylat (HEMA) og trietylenglykoldimetakrylat (TEGDMA) er to metakrylater som er mye brukt i resinbaserte tannbehandlingsmaterialer, og cellekulturene ble eksponert for disse i varierende konsentrasjon og varighet.

Tooth-coloured materials dominate restorative treatments in the Nordic countries today. The most recent developments have concentrated on monomers and filler particles. The present article discusses the composition of and results from laboratory studies on contemporary materials with specific focus on nanocomposites and the clinical relevance of laboratory studies. Furthermore polymerization by LED light curing units and the risk of release of hormone-like chemicals from composites are briefly discussed.