New animal model of extrinsic dental erosion-Erosive effect on the mouse molar teeth
Amela Tulek, Muhammad Saeed, Aida Mulic, Kjersti Refsholt Stenhagen, Tor Paaske Utheim, Hilde Kanli Galtung, Cuong Khuu, Minou Nirvani, Marthe Smedmoen Kristiansen and Amer Sehic | September 25th 2018
Human experiments on dental erosion are unethical because of the irreversible loss of dental hard tissues when exposed to acids. Therefore, studies using animal models are of high importance since they represent clinical situations. Based on the present results it can beconcluded that cola drink (phosphoric acid, pH=2.27) exhibited higher erosive effect on mouse mandibular molars compared to sports drink (citric acid, pH=3.39). This new animal model of extrinsic dental erosion where lesions of different severity can be created is suitable for further studies that will improve our understanding of the disease. The present method with transversely ground molars observed in SEM allows a registration of erosive lesions and lesion depths in small teeth like mouse molars. Both studies on the salivary influence (e.g. by using knockout mice) and the studies on the effect of fluoride on development of erosive lesions are warranted.