Investigation of biological effects of HEMA in 3D-organotypic co-culture models of normal and malignant oral keratinocytes -

Several in vitro studies utilizing 2-dimensional (2D) cell culture systems have linked 2-hydroxyethyl methacrylate (HEMA) with cytotoxic effects in oral mucosa and dental pulp cells. Although such studies are invaluable in dissecting the cellular and molecular effects of HEMA, there is a growing interest in the utilization of appropriate 3-dimensional (3D) models that mimic the structure of oral mucosa.

Toxicity of monomers -

The term “resin-based dental materials” refers to dental materials containing polymers, like composites, adhesives, cements and denture base material. Usually, these polymers are formed by in situ polymerization of methacrylate monomers.