Sub-lethal Concentrations of HEMA alter Protein Expression in Human Monocytes
Vibeke Barman Michelsen, Jan Tore Samuelsen, Jack Ansgar Bruun, Jon Einar Dahl, Einar Jensen and Ulf Ă–rtengren | September 20th 2014
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Several in vitro studies have shown increased intracellular level of reactive oxygen species (ROS) after exposure to 2-hydroxyethyl methacrylate (HEMA), a commonly used monomer in resin-based dental materials. This study aimed to investigate the initial changes of the proteome in a human monocyte cell line after exposure to HEMA by using Stable Isotope Labelling with Amino Acids in Cell culture (SILAC).