Antimicrobial and physicochemical characterization of endodontic sealers after exposure to chlorhexidine digluconate -

The primary aim of root canal treatment of teeth with apical periodontitis is to eliminate the microbial load from the root canal system and promote periapical healing. Meticulous mechanical debridement of the root canal system significantly reduces the bacterial load and is considered important in canal disinfection. However, complete elimination of all microorganisms is challenging, as viable bacteria potentially remain on the dentin walls and inside dentinal tubules, both in planktonic forms and biofilms. About 35% of the root canal area is left untouched when conventional rotary and hand instruments are used. Therefore, disinfection with irrigation solutions during root-canal treatment and thereafter obturation of the root canal are important factors to reduce the amount and growth of residual bacteria.

Antimicrobial photodynamic treatment of oral infections -

The increased occurrence of antibiotic resistance in general necessitates development of alternative antimicrobial drugs or methods. Further, certain cases of periodontitis respond poorly to conventional treatment. The principle of photodynamic therapy, currently used against certain cancers, may be a practical treatment modality for oral infections, presumably with low possibility for development of resistance. The treatment requires the presence of light-absorbing molecules (photosensitizer; PS) and irradiation with a light source emission that spectrally matches the light-absorption of the PS.