Phototherapy with sunlight for treatment of neonatal jaundice in low-income countries -

Abstract Neonatal jaundice, or hyperbilirubinemia, is a relatively common condition, and occurs in 2 out of 3 newborns. The condition is often transient. However, untreated hyperbilirubinemia can cause kernicterus and nervous system damage. Worldwide, over 114 000 infants die and 65 000 infants grow up with permanent brain damage due to this condition [1]. A […]

Effects of bilirubin and phototherapy on osmotic fragility and haematoporphyrin-induced photohaemolysis of normal erythrocytes and spherocytes. -

AIM: To study the effects of phototherapy on erythrocyte haemolysis in vitro and to determine possible differences in sensitivity to phototherapy between normal erythrocytes and spherocytes.
CONCLUSION: Bilirubin may make the plasma membrane of normal erythrocytes more fragile. Newborns with hereditary spherocytosis may be sensitive to phototherapy.

Bilirubin-induced cell death during continuous and intermittent phototherapy and in the dark. -

Continuous and intermittent light exposure caused the same degree of apoptotic cell death, while the cells underwent more necrotic death after intermittent exposure. Bilirubin was cytotoxic in the dark by both cell death mechanisms.

In vivo spectroscopy of jaundiced newborn skin reveals more than a bilirubin index -

The aims of this study were to improve the algorithms for calculating a transcutaneous bilirubin index (TcB), to follow the bilirubin concentrations during phototherapy and to evaluate possible changes in skin optical parameters such as pigmentation and erythema during phototherapy.