This study investigated the effect of surface nano-patterning on adhesion of an oral early commensal colonizer, Streptococcus mitis and the opportunistic pathogen Staphylococcus aureus and human fibroblasts (HDFa) in a laminar flow cell.

Commercial resin-based composites are mainly composed of dimethacrylate-based monomers, such as triethyleneglycol dimethacrylate (TEGDMA), inorganic fillers and a coupling agent. Cured resinbased composites have no antibacterial effect against oral bacteria and half of all fillings replaced are because of new caries . Chitosan is a natural carbohydrate polymer derived from the deacetylation of chitin. Chitosan has been shown to have an inhibitor effect on the adherence of oral bacteria onto human tooth surfaces.