Rat lung inflammatory responses after in vivo and in vitro exposure to various stone particles
Rune Becher, Ragna Bogen Hetland, Magne Refnes, Jon Einar Dahl, Hans J. Dahlman and Per E. Schwarze | September 20th 2001
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Rat lung alveolar macrophages and type 2 cells were exposed for 20 h in vitro to various stone particles with differing contents of metals and minerals (a type of mylonite, gabbro, feldspar, and quartz). The capability to induce the release of the inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and macrophage inflammatory protein-2 (MIP-2) was investigated.