The development of T cell-dominated inflammatory responses induced by sodium lauryl sulphate in mouse oral mucosa -

The effect of a single time exposure of SLS to the buccal mucosa of mice was compared to one application of the hapten OXA (oxazolone), evaluated by routine histology, immunohistochemistry and ELISA quantifications of cytokines. The SLS concentrations (2%, 4% and 8%) resulted in epithelial surface necrosis at 1-6 h, after 2-6 h accumulation of intra-epithelial neutrophils and at 24 h the main inflammatory cells were mononuclear.

DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. -

Mold spores and their associated mycotoxins have been suggested to be the cause of a variety of human health problems such as asthma and allergic rhinitis related to water-damaged indoor environments. Animal studies have shown that mycotoxins may cause a variety of adverse effects, including acute toxic effects and cancer

Pattern of cell death after in vitro exposure to GDMA, TEGDMA, HEMA and two compomer extracts -

In vitro exposure to chemical compounds in dental materials may cause cell death by apoptosis, necrosis or a combination of both. The aim of this paper was to evaluate aqueous extracts of freshly cured compomers Freedom (SDI) and F2000 (3M ESPE), and constituents identified in the extracts, GDMA (glycerol dimethacrylate), TEGDMA (triethylene glycol dimethacrylate) and HEMA (2-hydroxyethyl methacrylate) for their ability to induce necrosis and apoptosis in primary rat alveolar macrophages and the J744A1 macrophage cell line.

Bilirubin-induced cell death during continuous and intermittent phototherapy and in the dark. -

Continuous and intermittent light exposure caused the same degree of apoptotic cell death, while the cells underwent more necrotic death after intermittent exposure. Bilirubin was cytotoxic in the dark by both cell death mechanisms.

In vitro cell death induced by irradiation and chemicals relevant for dental applications; dose-response and potentiation effects. -

Abstract Resin-based dental materials polymerized using blue light are frequently used in dental practice and may come in contact with the oral mucosa. Remnants from oral hygiene product ingredients, such as sodium lauryl sulfate (SLS), add to the chemical exposure of the mucosa. The aim of the present in vitro study was to elucidate the […]