Methacrylate monomers lower the level of reduced glutathione and increase the in vitro sensitivity of cells to optical radiation -

Induction of cell death by optical radiation in the wavelength range 350–500 nm was significantly increased by commonly used methacrylate monomers, not mediated by absorption of radiation by the methacrylate monomers, but through a mechanism involving rapid reduction in the level of glutathione

HEMA reduces cell proliferation and induces apoptosis in vitro. -

Methacrylate monomers have been identified in aqueous extracts of freshly cured compomers. Both cells in the pulpal cavity and various cells of the oral mucosa can potentially be exposed to these leachables.