Proteome Changes Indicate Oxidative Stress and Protein Damage after Methacrylate Exposure in Human Monocyte Cell Line -

It has been suggested that reactive oxygen species are involved in HEMA toxicity. The upregulated levels of antioxidant enzymes and Hsp70 family proteins showed that HEMA exposure lead to cellular stress at concentrations that had no effect on cell viability.

TEGDMA and filler particles from dental composites additively attentuate LPS-induced cytokine release from the macrophage cell line RAW 264.7 -

Due to incomplete curing and material degradation, cells in the oral cavity may be exposed to monomers and filler particles from dental composite fillings. The objective of the present study was to investigate if combined exposures to particles and a methacrylate monomer from composite fillings resulted in additive effects on the macrophage immune response.

Dental monomers inhibit LPS-induced cytokine release from the macrophage cell line RAW264.7 -

Methacrylate monomers have been identified in aqueous extracts of freshly cured dental fillings. The hypothesis tested presently was that low concentrations of triethyleneglycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) alone or in combination interfere with the LPS-induced release of cytokines from the macrophage cell line RAW264.7.

Optical characterization of biomaterial/radiation-exposed oral mucosa by reflection spectroscopy -

Previously, we have reported data obtained from near-infrared reflection spectroscopy (NIRS) used to non-invasively monitor tissue changes after optical exposure. The results indicated that oral mucosa may be more sensitive than skin to blue light. In this pilot study, visible data from NIRS (VNIRS) was used to observe differences between exposure groups with respect to the following parameters: pigmentation (melanin index; MI), blood oxygenation (OX) and erythema (erythema index; EI).

Health hazard from resin-modified glass ionomer materials in pediatric dentistry. -

Resin-modified glass ionomer fillings are commonly used in pediatric dentistry. We have investigated possible exposure of monomers from such materials in vivo. Saliva was collected at three time points, pre-treatment, immediately after placement, and one week post-placement, from 20 patients aged seven to ten that had their first resin-based glass ionomer filling placed.