Establishing a macrophage model with relevance for oral methacrylate monomer exposures: Attenuated Staphylococcus aureus-induced cytokine release from human macrophages -

Leakage of unpolymerized methacrylate monomers after placement of methacrylate-containing polymeric dental materials leads to human exposure. Based on studies using murine macrophages and LPS from Escherichia coli (E. coli), dental monomers like 2-hydroxyethyl methacrylate (HEMA) are known to inhibit lipopolysaccharide (LPS) induced cytokine release.

NIOM Scientist attending the 58th Annual Meeting of the Society of Toxicology -

Senior scientist Jan T. Samuelsen is attending the 58th Annual Meeting of the Society of Toxicology in Baltimore, Maryland, March 10-14.

NIOM at NSFT winter meeting, 2019 -

The Norwegian Society of Pharmacology and Toxicology (NSFT) will hold its 47th annual winter meeting at Beitostølen, Norway, 24-27 January 2019

The dental monomer 2-hydroxyethyl methacrylate (HEMA) causes transcriptionally regulated adaptation partially initiated by electrophilic stress -

The airways of dental personnel can be exposed to low concentrations of HEMA on a daily basis. Thus, we aimed to explore altered gene expression in a bronchial epithelial cell line after exposure to “non-lethal” concentrations of HEMA, demonstrated to be 2 mM or below in the current model system. We show that the expression of a number of genes was altered in HEMA exposed cells.

Award for article on biological reactions -

The award for Best Scientific Review Article 2018 was given out today by the Swedish Dental Journal. We congratulate the winners!