In Vitro Effects of Dental Monomer Exposure – Dependence on the Cell Culture Model -

Methacrylate monomers are major components of resin-based biomaterials. The polymerization of these materials is never complete, and methacrylates leaking from cured materials cause exposure of patients. Only some selected methacrylates have thoroughly been tested for possible interaction with living cells. In the current study, we compared the effects of 2-hydroxyethyl-methacrylate (HEMA; a carefully studied methacrylate) […]

Ion release from three different dental alloys – effect of dynamic loading and toxicity of released elements -

The aims of this in vitro study were to assess if dynamic loading increases the metal ion release of selected dental alloys and to evaluate the cytotoxicity of the released metal ions

Clinical relevance of HEMA-toxicity studies -

Several studies show “leakage” of methacrylates during, and shortly after, treatment resin based dental materials. Read about the clinical relevance here.

Establishing a macrophage model with relevance for oral methacrylate monomer exposures: Attenuated Staphylococcus aureus-induced cytokine release from human macrophages -

Leakage of unpolymerized methacrylate monomers after placement of methacrylate-containing polymeric dental materials leads to human exposure. Based on studies using murine macrophages and LPS from Escherichia coli (E. coli), dental monomers like 2-hydroxyethyl methacrylate (HEMA) are known to inhibit lipopolysaccharide (LPS) induced cytokine release.

NIOM Scientist attending the 58th Annual Meeting of the Society of Toxicology -

Senior scientist Jan T. Samuelsen is attending the 58th Annual Meeting of the Society of Toxicology in Baltimore, Maryland, March 10-14.