Exposure to Dental Monomer Hydroxyethyl Methacrylate (HEMA) Induces Increased Transcription of Genes Involved in Oxidative Stress Responses -

Polymer-based restorative materials are widely used in dentistry. Cured materials contain unpolymerized methacrylate monomers which leak into the oral environment.

Cell toxicity of 2-hydroxyethyl methacrylate (HEMA): the role of oxidative stress -

In this study, the viability of human lung epithelial cells, BEAS-2B, was investigated after exposure to this monomer. Exposure to HEMA reduced the viability of the BEAS-2B cells as a result of increased apoptosis, interruption of the cell cycle, and decreased cell proliferation.

Detection and quantification of monomers in unstimulated whole saliva after treatment with resin-based composite fillings in vivo -

Resin-based dental restorative materials contain allergenic methacrylate monomers, which may be released into saliva after restorative treatment. Monomers from resin-based composite materials have been demonstrated in saliva in vitro; however, studies analyzing saliva after restorative therapy are scarce. The aim of this study was to quantify methacrylate monomers in saliva after treatment with a resin-based composite filling material.

Sammendrag av doktorgradsavhandling: «Toxicity of resin based dental restorative materials in vitro» -

Artikkelens hensikt er å belyse toksisiteten av utvalgte metakrylatmonomerer i modeller som kan relateres til cellulære mål in vivo. En cellelinje med opphav fra spyttkjertel-epitel og primære epiltelceller fra rottelunge ble valgt som relevante modellsystemer. Monomerene 2- hydroxyetylmetakrylat (HEMA) og trietylenglykoldimetakrylat (TEGDMA) er to metakrylater som er mye brukt i resinbaserte tannbehandlingsmaterialer, og cellekulturene ble eksponert for disse i varierende konsentrasjon og varighet.

Health hazard from resin-modified glass ionomer materials in pediatric dentistry. -

Resin-modified glass ionomer fillings are commonly used in pediatric dentistry. We have investigated possible exposure of monomers from such materials in vivo. Saliva was collected at three time points, pre-treatment, immediately after placement, and one week post-placement, from 20 patients aged seven to ten that had their first resin-based glass ionomer filling placed.