The dental monomer HEMA causes proteome changes in human THP‐1 monocytes -

Resin-based biomaterials are widely used in medical and dental treatment, and both clinicians and patients are exposed to the materials.
The present approach to analyzing the toxic potential of HEMA yielded information on interactions with living cells is not previously reported. This detailed information is of great value to make better predictions of possible side effects in the clinic.

The dental monomer 2-hydroxyethyl methacrylate (HEMA) causes transcriptionally regulated adaptation partially initiated by electrophilic stress -

The airways of dental personnel can be exposed to low concentrations of HEMA on a daily basis. Thus, we aimed to explore altered gene expression in a bronchial epithelial cell line after exposure to “non-lethal” concentrations of HEMA, demonstrated to be 2 mM or below in the current model system. We show that the expression of a number of genes was altered in HEMA exposed cells.

NIOM congratulates students from HIOA -

Bachelor students in bioengineering from Oslo and Akershus University of Applied Sciences (HIOA) have had a research stay in NIOM since Easter. Their efforts have resulted in two papers.

Relation between In Vitro Toxicity and the Thiol-Reactivity of Methacrylates in Resin-Based Biomaterials -

In this study we aimed to further map the suggested relation between GSH-depletion and methacrylate toxicity by comparing the molecular effects of methacrylate exposure and GSH-depletion by inhibiting GSH-synthesis.

Wavelength dependent increase in cell sensitivity after glutathione inhibition by methacrylate monomers. -

Reduction in the amount of glutathione (GSH) in cells can lead to increased sensitivity to physical and chemical agents. Methacrylate monomers (MM) are precursors of polymethacrylates which are used in dental and medical biomaterials and in a wide variety of other products. MM can increase cell sensitivity to long wavelength ultraviolet and visible radiation. The aim of this study is to elucidate if MM can induce sensitivity also to shorter wavelength radiation.