In Vitro Effects of Dental Monomer Exposure – Dependence on the Cell Culture Model

, and | June 11th 2020

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Methacrylate monomers are major components of resin-based biomaterials. The polymerization of these materials is never complete, and methacrylates leaking from cured materials cause exposure of patients. Only some selected methacrylates have thoroughly been tested for possible interaction with living cells. In the current study, we compared the effects of 2-hydroxyethyl-methacrylate (HEMA; a carefully studied methacrylate) […]
Clinical relevance of HEMA-toxicity studies

October 24th 2019

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Several studies show “leakage” of methacrylates during, and shortly after, treatment resin based dental materials. Read about the clinical relevance here.
Establishing a macrophage model with relevance for oral methacrylate monomer exposures: Attenuated Staphylococcus aureus-induced cytokine release from human macrophages

, , and | August 15th 2019

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Leakage of unpolymerized methacrylate monomers after placement of methacrylate-containing polymeric dental materials leads to human exposure. Based on studies using murine macrophages and LPS from Escherichia coli (E. coli), dental monomers like 2-hydroxyethyl methacrylate (HEMA) are known to inhibit lipopolysaccharide (LPS) induced cytokine release.
HEMA affect IL-1β release and phagocytosis in THP-1 macrophages

January 23rd 2019

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This abstract was presented at The Norwegian Society of Pharmacology and Toxicology (NSFT) 47th annual winter meeting at Beitostølen, Norway, 24-27 January 2019.

Toxicity of combined exposure of HEMA and nicotine in PE/CA-PJ49 cells

January 23rd 2019

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This abstract was presented at The Norwegian Society of Pharmacology and Toxicology (NSFT) 47th annual winter meeting at Beitostølen, Norway, 24-27 January 2019.