Solid dispersions for preparation of phototoxic supersaturated solutions for antimicrobial photodynamic therapy (aPDT): Studies on curcumin and curcuminoides L -

Curcumin is under investigation as a potential photosensitizer (PS) in antimicrobial photodynamic therapy (aPDT). The therapeutic potential of curcumin as a PS is limited by its low aqueous solubility, susceptibility to hydrolytic and photolytic degradation, and limited phototoxicity toward Gram negative (G−) bacteria.

Photoinactivation of Stahpylococcus epidermidis biofilms and suspensions by the hydrophobic photosensitizer curcumin- effect of selected nanocarrier Studies of curcumin and curcuminoides XLVII -

Solubilization and stabilization from rapid degradation by the use of nanocarriers are necessary to exploit curcumin’s phototoxic potential towards pathogenic bacteria.

Phototoxicity of curcumin loaded alginate foams to Enterococcus faecalis and Escherichia coil in vitro -

Curcumin loaded alginate foams are proposed for application in antimicrobial photodynamic therapy of infected wounds. The drug loaded foams were formulated to provide a burst release of the photosensitizer when hydrated.