Effects of Nrf2 signaling on cytotoxicity induced by HEMA from dental biomaterials -

INTRODUCTION Resin-based biomaterials used in dentistry consist of methacrylate monomers that are polymerized in situ. The conversion to polymer is never complete and cause patient exposure to electrophilic monomers such as 2-hydroxyethyl methacrylate (HEMA). In addition, dental personnel are exposed through handling of uncured materials. In vitro, methacrylates are reported to be cytotoxic in a […]

Nrf2 Signaling and Cytoprotection in Human Epithelial Airway Cells Exposed to HEMA -

Methacrylates are common constituents of resin-based biomaterials. These materials cure by polymerization of methacrylate monomers, but incomplete polymerization causes leakage and patient exposure to the electrophile monomers.

NIOM to present at ESB2017 in Athens -

NIOMs Senior Engineers Else Morisbak and Torbjørn Knarvang are participating at the 28th annual conference of the European Society for Biomaterials (ESB) in Athens, Greece.

The dental monomer hydroxyethyl methacrylate (HEMA) counteracts lipopolysaccharide-induced IL-1β release-Possible role of glutathione. -

HEMA reduced GSH levels and decreased IL-1β release from LPS-stimulated macrophages. The role of GSH in the regulation of IL-1β release was explored. GSH depletion alone could not explain the attenuation of LPS-induced IL-1β release. Electrophile reactivity toward other cellular molecules is a new working hypothesis

Effect of Components in Resin-Based Dental Restoratives on Protein-S-Glutathionylation -

Protein S-glutathionylation (PSSG) is the reversible formation of mixed disulfides between glutathione and protein cysteinyl residues.