Adhesion of Escherichia Coli to Nanostructured Surfaces and the Role of Type 1 Fimbriae -

In this study a method of producing a large number of identical nanostructured surfaces is presented. E. coli wild type and deletion mutants of the type 1 fimbriae monomers FimA or FimH were tested for their ability to adhere to such surfaces with different interpillar distance of 100, 250, and 500 nm, respectively. An increase in interpillar distance (reduced surface coverage) was associated with reduced adhesion of E. coli wild type and the deletion mutants. In addition, the presence of a functional type 1 fimbria decreased adhesion to the nanopatterned surfaces in comparison to deletion mutants, leading us to the conclusion that there is a relationship between presence of a functional fimbriae and adhesion towards tested surfaces. The hypothesis that the presence of fimbriae had an effect on bacterial attachment to nanostructured surfaces was verified. These current results could provide insight into development of new nano-patterned structures with anti-adhesion bacterial properties.

Thiophenone Attenuates Enteropathogenic Escherichia coli O103:H2 Virulence by Interfering with AI-2Signaling -

Interference with bacterial quorum sensing communication provides an anti-virulence strategy to control pathogenic bacteria.

Cyclodextrins influence on lumichrome solubilization and phototoxic efficacy against bacteria. -

Lumichrome (Lc) is a photodegradation product of riboflavin. It is more photostable and a more efficient photogenerator of singlet oxygen than riboflavin. Lc absorbs mainly in the UVA range. Cyclodextrins (CDs) are reported to be very efficient solubility enhancers of Lc in aqueous solutions. A 1:1 inclusion complex has been predicted between Lc and α and βCDs (Terekhova, Kumeev et al. 2011). The aim of the present study was to evaluate the influence of CDs on solubility and on the bacterial phototoxicity of Lc in vitro.

Solid dispersions for preparation of phototoxic supersaturated solutions for antimicrobial photodynamic therapy (aPDT) Studies on curcumin and curcuminoides L -

Curcumin is under investigation as a potential photosensitizer (PS) in antimicrobial photodynamic therapy (aPDT). The therapeutic potential of curcumin as a PS is limited by its low aqueous solubility, susceptibility to hydrolytic and photolytic degradation, and limited phototoxicity toward Gram negative (G-) bacteria.

A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. -

Curcumin, bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, has potential as a photosensitiser for photodynamic treatment of localised superficial infections in e.g., the mouth or skin.