Thiophenone Attenuates Enteropathogenic Escherichia coli O103:H2 Virulence by Interfering with AI-2Signaling -

Interference with bacterial quorum sensing communication provides an anti-virulence strategy to control pathogenic bacteria.

Cyclodextrins influence on lumichrome solubilization and phototoxic efficacy against bacteria. -

Lumichrome (Lc) is a photodegradation product of riboflavin. It is more photostable and a more efficient photogenerator of singlet oxygen than riboflavin. Lc absorbs mainly in the UVA range. Cyclodextrins (CDs) are reported to be very efficient solubility enhancers of Lc in aqueous solutions. A 1:1 inclusion complex has been predicted between Lc and α and βCDs (Terekhova, Kumeev et al. 2011). The aim of the present study was to evaluate the influence of CDs on solubility and on the bacterial phototoxicity of Lc in vitro.

Solid dispersions for preparation of phototoxic supersaturated solutions for antimicrobial photodynamic therapy (aPDT) Studies on curcumin and curcuminoides L -

Curcumin is under investigation as a potential photosensitizer (PS) in antimicrobial photodynamic therapy (aPDT). The therapeutic potential of curcumin as a PS is limited by its low aqueous solubility, susceptibility to hydrolytic and photolytic degradation, and limited phototoxicity toward Gram negative (G-) bacteria.

A screening of curcumin derivatives for antibacterial phototoxic effects studies on curcumin and curcuminoids. XLIII. -

Curcumin, bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, has potential as a photosensitiser for photodynamic treatment of localised superficial infections in e.g., the mouth or skin.

Formulation and Bacterial Phototoxicity of Curcumin Loaded Alginate Foams for Wound Treatment Applications: Studies on Curcumin and Curcuminoides XLII -

Curcumin loaded alginate foams are proposed for application in antimicrobial photodynamic therapy of infected wounds. The drug loaded foams were formulated to provide a burst release of the photosensitizer when hydrated