Leakage of unpolymerized methacrylate monomers after placement of methacrylate-containing polymeric dental materials leads to human exposure. Based on studies using murine macrophages and LPS from Escherichia coli (E. coli), dental monomers like 2-hydroxyethyl methacrylate (HEMA) are known to inhibit lipopolysaccharide (LPS) induced cytokine release.

Resin-based biomaterials are widely used in medical and dental treatment, and both clinicians and patients are exposed to the materials.
The present approach to analyzing the toxic potential of HEMA yielded information on interactions with living cells is not previously reported. This detailed information is of great value to make better predictions of possible side effects in the clinic.

BPA has been reported to leach from some resin-based dental restorative materials and materials used for orthodontic treatment. To confirm and update previous findings, especially in light of the new temporary lower threshold value for tolerable daily BPA intake, leaching of BPA from 4 composite filling materials, 3 sealants and 2 orthodontic bonding materials were investigated.

NIOM’s purpose is to ensure that the dental materials and products, used in dental care in the Nordic countries, meet the health and technical requirements which are in place regarding development in the area.