Biotransformation enzymes and lung cell response to 2-hydroxyethyl-methacrylate.

, , , , and | November 29th 2011

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The aim of this in vitro study was to investigate possible involvement of cytochrome P450 (CYP) enzymes in modifying the toxic potential of 2-hydroxyethyl-methacrylate (HEMA). Primary cultures of CYP expressing rat alveolar type 2 cells were exposed to varying concentrations of HEMA. Nuclear translocation of aryl hydrocarbon receptor (AhR) after HEMA exposure (100 μM) was demonstrated by immunocytochemical staining.

Methacrylate monomers lower the level of reduced glutathione and increase the in vitro sensitivity of cells to optical radiation

and | September 23rd 2010

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Induction of cell death by optical radiation in the wavelength range 350–500 nm was significantly increased by commonly used methacrylate monomers, not mediated by absorption of radiation by the methacrylate monomers, but through a mechanism involving rapid reduction in the level of glutathione

DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin.

, , , , , , , , and | May 13th 2010

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Mold spores and their associated mycotoxins have been suggested to be the cause of a variety of human health problems such as asthma and allergic rhinitis related to water-damaged indoor environments. Animal studies have shown that mycotoxins may cause a variety of adverse effects, including acute toxic effects and cancer