Phototherapy with sunlight for treatment of neonatal jaundice in low-income countries -

Abstract Neonatal jaundice, or hyperbilirubinemia, is a relatively common condition, and occurs in 2 out of 3 newborns. The condition is often transient. However, untreated hyperbilirubinemia can cause kernicterus and nervous system damage. Worldwide, over 114 000 infants die and 65 000 infants grow up with permanent brain damage due to this condition [1]. A […]

Formation of photoproducts and cytotoxicity of bilirubin irradiated with turquoise and blue phototherapy light. -

To compare a new turquoise (“green”) fluorescent phototherapy lamp (490 nm) with a conventional blue phototherapy lamp (450 nm) with respect to cytotoxicity and photochemical effects of bilirubin.
Conclusion: The two lamps were similar in the formation of therapeutically relevant photoproducts, but the blue lamp showed potential in forming more photo-oxidation products and in causing more severe cellular damage in the presence of bilirubin.

Effects of bilirubin and phototherapy on osmotic fragility and haematoporphyrin-induced photohaemolysis of normal erythrocytes and spherocytes. -

AIM: To study the effects of phototherapy on erythrocyte haemolysis in vitro and to determine possible differences in sensitivity to phototherapy between normal erythrocytes and spherocytes.
CONCLUSION: Bilirubin may make the plasma membrane of normal erythrocytes more fragile. Newborns with hereditary spherocytosis may be sensitive to phototherapy.

Bilirubin-induced cell death during continuous and intermittent phototherapy and in the dark. -

Continuous and intermittent light exposure caused the same degree of apoptotic cell death, while the cells underwent more necrotic death after intermittent exposure. Bilirubin was cytotoxic in the dark by both cell death mechanisms.