Physicochemical characterisation and antimicrobial phototoxicity of an anionic porphyrin in natural deep eutectic solvents -

The purpose of this study was to investigate preparations of an anionic porphyrin, meso-tetra-(4-carboxyphenyl)-porphine (TCPP), solubilised in NADES, with regard to their physicochemical and antibacterial properties.

Improved antibacterial phototoxicity of a neutral porphyrin in natural deep eutectic solvents -

Neutral porphyrins for antibacterial photodynamic therapy (aPDT) have received little attention due to their tendency to aggregate in aqueous media and reports of low phototoxic effect. These compounds may be less toxic to cells than positively and negatively charged photosensitisers.

Photoinactivation of bacteria by lumichrome: Influence of formulation and preparation method. -

Lumichrome, a photodegradation product of riboflavin, is an endogenous compound in humans. The compound is more photostable and a more efficient photogenerator of singlet oxygen than riboflavin. It absorbs radiation in the UVA and blue light region, which can be an advantage in aPDT of superficial infections.

Supersaturation and supersaturated drug delivery systems to surpass the outher membrane barriers of Gram negative bacteria in antimicrobial photodynamic therapy (aPDT). -

Bacterial resistance towards antibiotics is increasing. Especially Gram negative (G-) pathogenic bacteria are responsible for serious nosocomial infections. Novel treatment strategies such as antimicrobial photodynamic therapy (aPDT) are needed to fight such infections.

Solid dispersions for preparation of phototoxic supersaturated solutions for antimicrobial photodynamic therapy (aPDT) Studies on curcumin and curcuminoides L -

Curcumin is under investigation as a potential photosensitizer (PS) in antimicrobial photodynamic therapy (aPDT). The therapeutic potential of curcumin as a PS is limited by its low aqueous solubility, susceptibility to hydrolytic and photolytic degradation, and limited phototoxicity toward Gram negative (G-) bacteria.