Formulation and characterisation of lyophilised curcumin solid dispersions for antimicrobial photodynamic therapy (aPDT) -

Curcumin is currently under investigation as a potential photosensitiser in antimicrobial photodynamic therapy (aPDT). Previous studies have demonstrated high phototoxicity towards Gram-positive (G+) bacteria, but lower effect on Gram-negative (G-) bacteria.

Application of nanovehicles in preparations for antimicrobial photodynamic therapy (aPDT) -

Topical application is the preferred administration route of the photosensitizer (PS) in antimicrobial photodynamic therapy (aPDT), e.g. for the treatment of infections in the oral cavity or skin. The drug formulation should allow for a sufficient contact time between the preparation and tissue, a rapid release of PS, and a selective uptake of PS in bacteria.