Genes a factor in fighting dental erosion

– We looked into the association between the locus and erosion on a group of 16-18 year-olds, Mulic says.

 

 

 

 

 

 

 

 

 

 

 

 

 

– The genotypic analyses revealed an association between chromosome X marker rs1324156 and erosive tooth wear phenotype, Mulic says.

Erosive tooth wear is a growing problem. While the causes are many, from increased consumption of soda and acidic food, we now know that genes play a role too. A recent NIOM study delves into the subject matter.

– Considering that the chromosome X locus was shown to be associated with dental caries, we wanted to look for the association between a certain locus and erosive tooth wear when dietary habits are considered as a co-factor, says Aida Mulic.

Mulic is a senior scientist at NIOM. To study this particular locus, Xq26.1 – 27.3, she teamed up with Alexandre Rezende Vieira, Mariana Bezamat, Jenny Bogstad Søvik, Amer Sehic and Amela Tulek.

Comprehensive analysis

– We looked into the association between the locus and erosion on a group of 16-18 year-olds, Mulic says.
They gathered saliva samples, erosive wear experience data, and dietary information. The data was then used for genotyping analyses. Afterwards they used logistic regression to analyze and consider diet and oral hygiene data, with the assumption that erosive tooth wear is a complex gene-environment model.

Significant association

– The genotypic analyses revealed an association between chromosome X marker rs1324156 and erosive tooth wear phenotype, Mulic says.

In the study, logistic regression analysis showed that in the presence of less common allele of rs12687601 and rs1324156, erosive tooth wear is more likely to develop, when associated with acidic dietary variables from the questionnaire.

The results indicate that erosive tooth wear may be result of interactions between dietary and genetic factors, Mulic says.

 

Photo by filadendron istock: Two youngsters eating a meal and drinking juice.

Reference:

Association of locus Xq26.1 – 27.3 with Erosive Tooth Wear Phenotypes in a Group of Adolescents
Mulic A, Vieira AR, Bezamat M, Søvik JB, Sehic A, Tulek A
Caries Res. 2023 Jan 10, DOI: 10.1159/000529015, ISSN: 0008-6568 (Print), eISSN: 1421-976X (Online)

NIOM Newsletter February 2023

print