The amalgam controversy has put an increased focus on the risk/benefit of resin-based dental materials. One aspect is that estrogen mimicking substances, otherwise related to pollution from plastic products, could be released from dental materials. Environmental research has shown that hormone disruptors of this kind lead to ambiguous genitalia and lowered reproduction in fish and wild animals. Two such substances, Bisphenol-A (BPA) associated with the Bis-GMA monomer and a phthalate softener are present in some dental materials. Animal studies have indicated adverse effects at low doses of these substances. Norwegian authorities have therefore banned BPA and phthalate-containing products intended for small children. Neonatal medicine has paid particular attention to substances of this kind derived from medical equipment.
Dental research has shown that small quantities of BPA and phthalates are eluted from resin-based materials and may be traced in saliva for a short period of time. In vitro eluates of this kind may increase estrogenic indicators in cell cultures. Dental fissure sealants have been given particular attention because of their application in child dental care. However, the exposure to BPA and phthalates associated with dental treatment has been evaluated by European and American health authorities without concerned remarks for reasons of minute quantities and short time exposure.
Reproduksjonsskadelige stoffer i dentale plastmaterialer?
Nils Jacobsen og Arne Hensten
Nor Tannlegeforen Tid 2010; 120: 748—52