Presence of 6PPD-quinone in runoff water samples from Norway using a new LC–MS/MS method -

The chemical 6PPD-quinone is highly toxic to some fish species of the Oncorhynchus and Salvelinus genera and is the oxidation product of the common car tire additive 6PPD. We present a new sample preparation method that involves liquid-liquid extraction of water samples followed by silica-based solid phase extraction prior to LC–MS/MS analysis. The new sample preparation method showed good […]


NIOM’s Maria Pain and Aida Mulic at this year’s NTF in Norway. Pain held a lecture about Microbiology in dentistry.

Forskerstilling – Kjemi -

Det er ledig en fast stilling som forsker i kjemi ved Nordisk institutt for odontologiske materialer (NIOM). Vi søker etter en aktiv medarbeider med god kompetanse innen kjemi og interesse for biomaterialer. Biomaterialer for odontologiske og medisinske formål er i sterk utvikling, og vi ønsker å forsterke vår kunnskap på dette området. Stillingen vil hovedsakelig […]

Coronavirus – measures taken by NIOM -

NIOM support and follow the national guidelines regarding the COVID-19 outbreak. We have taken the recommended precautions to ensure the safety of our people while staying operational, and carrying out scheduled test activities.

Publications 2021 -

NIOM’s publications from 2021.

Shimadzu UV-2550 spectrophotometer -

The UV-2550 double monochromator design provides a high-energy throughput optical system with ultra-low stray light. While featuring low stray light, excellent energy characteristics are provided over an extremely wide wavelength range. Qualitative analysis can be used to identify certain classes of compounds both as pure samples and in biological mixtures. This type of spectroscopy is […]

TMA: Thermomechanical analysis -

In terms of dental materials, thermal properties are of high importance, especially when different materials are to be joined together. Dental crowns or bridges consist of metal alloy or ceramic cores covered with veneering ceramics. These materials undergo changes during heating and cooling. Thermomechanical analysis, TMA, can provide valuable information on materials that influence on […]

FT-IR: Fourier Transform Infrared Spectroscopy -

NIOM posesses a Varian model 670 FT-IR (Agilent Technologies) equipped with ATR, DRIFT, and transmission accessories. The instrument is used among others to find the degree of conversion of polymer-based dental materials. Molecules interact with light over a wide wavelength range, and the interaction between light and molecules will form a pattern that can give […]

Microscopes for Scientific studies -

NIOM has several microscopes for research of different topics. For biological science (cells and bacteria): Confocal Laser scanning microscope, CLSM, system FV1200, Olympus BX61WI, equipped with two lasers, a diode laser emitting at 473 nm and a helium-neon laser emitting at 543 nm, 10X and 60X with oil or water (see NIOM Newsletter August 2016). […]

Universal testing machines -

NIOM possesses equipment for mechanical testing of dental materials. Whether it concerns polymer-based materials, metals, alloys, cements or ceramics we are able to offer testing of the mechanical elastic, plastic and fracture properties of dental materials. Two testing machines are widely used for research projects and testing of dental materials according to different ISO standards. […]

Digital dental X-ray system -

NIIOM has a digital dental x-ray system using phosphor plates and a digital scanner. The system is used for measuring radio-opacity of dental materials according to ISO standards, such as ISO 6876 (Endodontic materials) and ISO 4049 (Polymer-based restorative materials). By making a specimen of the specific material and place it beside an aluminium step wedge, […]

Sample preparation -

Casting machinesNIOM has two casting machines for casting different dental alloys. A vacuum press machine, Heraeus Combilabor CL-G2002, for the casting of precious and low-precious alloys, and a vacuum pressure induction casting machine, Heracast iQ, for casting of base metals. The casting machines are primarily used to cast samples for testing according to ISO 22674 […]

Antimicrobial photodynamic therapy for treatment of oral biofilm associated diseases – where we are -

Abstract from Håkon Valens lecture at symposium PDT-4. Human antimicrobial PDT. ESP-IUPB World Congress, Light & Life, Barcelona, Spain. August 25-30. 2019. Bacteria in the oral cavity lives primarily in polymicrobial biofilms. Oral mature biofilms may contain several hundred different bacterial species, and over 600 different species have been shown to colonize the oral cavity. […]

Antibacterial photodynamic therapy for treatment of oral biofilms related to periodontal and peri-implant diseases -

Abstract from Håkon Valens lecture at symposium MED-10 Dentistry. (Organized by Ellen Bruzell). ESP-IUPB World Congress, Light & Life, Barcelona, Spain. August 25-30. 2019. Oral biofilm formation around teeth and dental implants may cause inflammation of the surrounding tissue, which may lead to breakdown of the attachment of the tooth or implant. Ultimately, if left […]

Photostability of an anionic porphyrin in natural deep eutectic solvents (NADES) -

Abstract from Krister Grønliens lecture at symposium PDT-4. Human antimicriobial PDT. ESP-IUPB World Congress, Light & Life, Barcelona, Spain. August 25-30. 2019. Natural deep eutectic solvents (NADES) is a group of eutectics that is based solely on environmental-friendly (“Green”) components. These solvents have unique solubilizing properties; i.e. they are more polar than water but can […]

NIOM aquires open material 3D-printer -

3D-printers open up exciting new fields of research, treatment and testing. This makes one a natural acquisition for NIOM’s instrument park. Read more about which printer we chose, and why.

Scientist returns to NIOM -

NIOM is pleased to announce the return of Simen E. Kopperud, as Senior Scientist, after a two years absence

HEMA affect IL-1β release and phagocytosis in THP-1 macrophages -

This abstract was presented at The Norwegian Society of Pharmacology and Toxicology (NSFT) 47th annual winter meeting at Beitostølen, Norway, 24-27 January 2019.

Toxicity of combined exposure of HEMA and nicotine in PE/CA-PJ49 cells -

This abstract was presented at The Norwegian Society of Pharmacology and Toxicology (NSFT) 47th annual winter meeting at Beitostølen, Norway, 24-27 January 2019.

Using natural deep eutectic solvents (NADES) as photosensitiser solubiliser -

ABSTRACT   Background and Objective Several photosensitisers (PS) used in experimental bacterial phototoxicity studies are poorly water- soluble and tend to aggregate. Specific vehicles can improve and control properties such as aqueous solubility, aggregation and photoreactivity. Natural deep eutectic solvents (NADES) are eutectic mixtures of two or more naturally occurring metabolite components in a specific […]

Effects of Nrf2 signaling on cytotoxicity induced by HEMA from dental biomaterials -

INTRODUCTION Resin-based biomaterials used in dentistry consist of methacrylate monomers that are polymerized in situ. The conversion to polymer is never complete and cause patient exposure to electrophilic monomers such as 2-hydroxyethyl methacrylate (HEMA). In addition, dental personnel are exposed through handling of uncured materials. In vitro, methacrylates are reported to be cytotoxic in a […]

Cell Toxicity of Nicotine and 2-hydroxyethylmethacrylate (HEMA) -

Abstract Objectives Snus is a type of smokeless tobacco widely used in the Nordic countries. A range of adverse health effects is associated with use of snus, and it is suggested that nicotine may mediate many of these effects. A major component in most resin based dental restoratives is methacrylate monomers. Commonly, these materials polymerize […]

Temperature Changes in Test Specimens During Thermal Cycling -

Abstract Objectives Thermal cycling procedure using water bath of 5 C and 55 C is a commonly used method to stress and age test specimens in laboratory testing. Typically, test specimens are kept in each of the water bath for 20 sec with 3 sec transfer time using 5000 – 10 000 cycles. After the […]

HEMA Alters Protein S-glutathionylation in BEAS-2B Cells -

Abstract Objectives 2-Hydroxyethyl methacrylate (HEMA) is a major component of many resin-based dental materials. During and after treatment with these materials, both dental personnel and patients are exposed to HEMA. In vitro studies have demonstrated a cytotoxic potential of HEMA, and reactivity towards cysteine (a nucleophilic amino acid (AA)) in glutathione (GSH) is assumed to contribute to […]

Antibacterial and anti-adhesive properties of Pluronic® F127 solutions in the absence or presence of photoactivation -

INTRODUCTION Staphylococcus epidermidis, a human skin commensal, is the most frequent isolate from infections of medical indwelling devices. This fact reflects the ubiquitous nature of S. epidermidis on the skin and the risk of contamination of a medical device before or during insertion1. A counteraction strategy is to develop coatings of medical devices to reduce […]

Are nanoparticles used in dental materials neurotoxic? -

Nanoparticles (NPs) is used in dentistry to give certain materials desired properties, such as grinding effect in toothpaste or to change viscosity in nanocomposite, but also occurs naturally. NPs are defined as particles ranging from 1 nm to 100 nm in one dimension1. Use of nanomaterials improves properties of materials, but the potential for adverse […]

Effects of HEMA on protein S-glutathionylation in BEAS-2B cells -

Introduction Resin-based dental materials are a common first choice when restoring dental function. These materials never cure completely and both dental personnel and patients are exposed to methacrylate monomers, one main component in these materials. A concern regarding possible side effects these materials may induce has been the motivation of several in vitro studies. A […]

Chitosan and chitosan-oligosaccharide as antimicrobial agents in ZOE restorative materials -

This highlights the importance of the antibacterial properties of the material, to kill remaining bacteria during excavation and bacteria that may penetrate the coronal restoration of an endodontically treated tooth.