Research improves the clinical relevance of in vitro biocompatibility tests
The research strategy is changing to yield more clinically relevant knowledge.
Such knowledge is beginning to be used to develop more accurate in vitro biocompatibility tests.
The biocompatibility of resin-based dental biomaterials has been studied widely, mainly by laboratory studies (in vitro). In a newly published paper, Samuelsen and Dahl overview available data and describe how the research strategy is changing to yield more clinically relevant knowledge.
Laboratory research over many years has revealed a potential for biological effects of resin-based dental materials. Further, allergic reactions to these materials are observed in clinical situations. The review by Samuelsen and Dahl summarizes current research findings and biocompatibility testing strategies of such materials. The authors additionally address evolving research on molecular events caused by exposure to these materials. A more accurate understanding of the biological aspects that result from such research yields unique insight into the responses of exposed cells. Such knowledge is beginning to be used to develop more accurate in vitro biocompatibility tests that are likely to improve their clinical relevance.
The figure schematically outlines the research-based development of new standardized biomaterial test protocols.