Di-n-butyl phthalate modifies PMA-induced macrophage differentiation of THP-1 monocytes via PPARγ. -

The present study was part of the research project Inhalation and prenatal exposure to phthalates: influence on airway immunology, conducted at the Norwegian Institute of Public Health, and was funded by the Norwegian research council (Research grant number: 228129).

Digital evaluation of marginal and internal fit of single-crown fixed dental prostheses -

The adaptation of single-crown fixed dental prostheses (FDPs) is a subject of great interest in the research community. Many investigations have been published, and a variety of evaluation methods have been used to determine the fit accuracy of prosthetics.
Many of the methods required manual measurements of the gap between the restoration and the abutment. With the introduction of CAD/CAM techniques, digital tools started being used for evaluating the adaptation of FDPs.
In this study, a tabletop dental scanner was used. It is anticipated that in a clinical setting, an intraoral scanner is sufficient, at least for single-crown FDPs.

Biofilms and their properties -

Oral biofilm‐associated diseases, such as caries and periodontitis, represent global public health challenges. The diseases develop as a result of dysbiosis of the oral microbiome. There is a long tradition in medicine for treating bacterial infections by the use of antibiotics. Unfortunately, biofilm bacteria are significantly less sensitive to antibacterial agents than are their planktonic counterparts. This property of biofilm challenges us in our daily work as dentists, and might explain why many oral prophylactic agents predicted to be efficacious in vitro, only show marginal effect in vivo.

New animal model of extrinsic dental erosion-Erosive effect on the mouse molar teeth -

Human experiments on dental erosion are unethical because of the irreversible loss of dental hard tissues when exposed to acids. Therefore, studies using animal models are of high importance since they represent clinical situations. Based on the present results it can beconcluded that cola drink (phosphoric acid, pH=2.27) exhibited higher erosive effect on mouse mandibular molars compared to sports drink (citric acid, pH=3.39). This new animal model of extrinsic dental erosion where lesions of different severity can be created is suitable for further studies that will improve our understanding of the disease. The present method with transversely ground molars observed in SEM allows a registration of erosive lesions and lesion depths in small teeth like mouse molars. Both studies on the salivary influence (e.g. by using knockout mice) and the studies on the effect of fluoride on development of erosive lesions are warranted.

Optimizing quality and safety of dental materials -

Optimizing quality and safety of resin‐based materials need coherent strategies. Proper handling and polymerization increase the rate of conversion and thus minimize the content of residual monomers. Measures to reduce biofilm accumulation at the tooth‐restoration interface could prevent or reduce the most common reason for restoration failure, recurrent caries.

Presence and leaching of bisphenol a (BPA) from dental materials -

BPA has been reported to leach from some resin-based dental restorative materials and materials used for orthodontic treatment. To confirm and update previous findings, especially in light of the new temporary lower threshold value for tolerable daily BPA intake, leaching of BPA from 4 composite filling materials, 3 sealants and 2 orthodontic bonding materials were investigated.

Nrf2 Signaling and Cytoprotection in Human Epithelial Airway Cells Exposed to HEMA -

Methacrylates are common constituents of resin-based biomaterials. These materials cure by polymerization of methacrylate monomers, but incomplete polymerization causes leakage and patient exposure to the electrophile monomers.

Lysherding – så enkelt og så vanskelig. -

For kort herdetid kan føre til mangelfull herding (polymerisasjon) av komposittmaterialer. For lang herdetid kan øke risiko for varmeskade på oralt bløtvev og pulpa. Herdelampens lysstyrke (irradians) reduseres når avstanden øker mellom lysutgangen og materialflaten.
For å opprettholde lysdosen som kreves for tilstrekkelig herding, må herdetiden økes. Kortere lysherdingstider enn omtrent 10 sekunder kan føre til utilstrekkelig herding av materialet.

Side effects of chemical compounds used in dental clinics -

The work at a dental clinic implies getting in contact with different chemical substances, which may cause temporary or permanent injury to the staff, primarily allergic reactions, but also local irritation, carcinogenic or toxic effects. Dentists and dental assistants belong to the professional groups most frequently experiencing work-related eczema.

Redefining the Phenotype of Dental Caries -

To our knowledge, this is the first study to separate patients into more discrete groups based on dental caries experience defined from longitudinal data and the first to study acute increases in DMFT score between two time points. Our hope with doing so is to provide more power in our predictions of genetic influences of dental caries and perhaps lead to better ways of studying the disease based on more specific categorizations of phenotypes.