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The aims of the study were to investigate the release of elements from, and the biological response in vitro to, cobalt–chromium alloys and other base–metal alloys used for the fabrication of metal-ceramic restorations. Corrosion test showed similar element release from base-metal alloys compared to noble alloys such as gold. All alloys expressed low element release in the immersion test, no cytotoxic effect in the MTT test, and were rated non-irritant in the HET-CAM test.

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