New method: Skin irritation test for evaluation of medical device extracts
Although questions have been raised regarding reproducibility and animal welfare, the rabbit Draize eye test has remained an accepted method to evaluate skin irritation for many years. For the last decade, in vitro 3D skin models are developed to predict and classify skin irritation potential of chemicals. Several methods have been validated by ECVAM (European Centre for the Validation of Alternative Methods) and achieved regulatory acceptance internationally for replacement of the rabbit Draize test. Among the approved skin systems is the Epiderm™ system from Matek.